Effect of Hemagglutinin Glycosylation on Influenza Virus Susceptibility to Neuraminidase Inhibitors

Inhibition of neuraminidase (NA) activity prevents release of progeny virions from influenza-infected cells and removal of neuraminic (sialic) acid moieties from glycans attached to hemagglutinin (HA). Neuraminic acid moieties situated near the HA receptor-binding site can reduce the efficiency of v...

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Bibliographic Details
Main Authors: Mishin, Vasiliy P., Novikov, Dmitri, Hayden, Frederick G., Gubareva, Larisa V.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1211522/
https://ncbi.nlm.nih.gov/pubmed/16160169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.19.12416-12424.2005
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