Neuraminidase Mutations Conferring Resistance to Oseltamivir in Influenza A(H7N9) Viruses

Human infections by avian influenza A(H7N9) virus entail substantial morbidity and mortality. Treatment of infected patients with the neuraminidase (NA) inhibitor oseltamivir was associated with emergence of viruses carrying NA substitutions. In the NA inhibition (NI) assay, R292K conferred highly r...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Marjuki, Henju, Mishin, Vasiliy P., Chesnokov, Anton P., De La Cruz, Juan A., Davis, Charles T., Villanueva, Julie M., Fry, Alicia M., Gubareva, Larisa V.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Vaccines and Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442539/
https://ncbi.nlm.nih.gov/pubmed/25740997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03513-14
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