Sitamaquine Overcomes ABC-Mediated Resistance to Miltefosine and Antimony in Leishmania

Although oral miltefosine represented an important therapeutic advance in the treatment of leishmaniasis, the appearance of resistance remains a serious threat. LMDR1/LABCB4, a P-glycoprotein-like transporter included in the Leishmania ABC (ATP-binding cassette) family, was the first molecule shown...

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Main Authors: Pérez-Victoria, José M., Bavchvarov, Boris I., Torrecillas, Iván R., Martínez-García, Marta, López-Martín, Carmen, Campillo, Mercedes, Castanys, Santiago, Gamarro, Francisco
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147638/
https://ncbi.nlm.nih.gov/pubmed/21646479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00065-11
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