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Sitamaquine Sensitivity in Leishmania Species Is Not Mediated by Drug Accumulation in Acidocalcisomes

Sitamaquine (WR6026), an 8-aminoquinoline derivative, is a new antileishmanial oral drug. As a lipophilic weak base, it rapidly accumulates in acidic compartments, represented mainly by acidocalcisomes. In this work, we show that the antileishmanial action of sitamaquine is unrelated to its level of...

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Detalhes bibliográficos
Main Authors: López-Martín, Carmen, Pérez-Victoria, José María, Carvalho, Luis, Castanys, Santiago, Gamarro, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573096/
https://ncbi.nlm.nih.gov/pubmed/18794384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00964-08
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