Topoisomerase 1 and Single-Strand Break Repair Modulate Transcription-Induced CAG Repeat Contraction in Human Cells

Expanded trinucleotide repeats are responsible for a number of neurodegenerative diseases, such as Huntington disease and myotonic dystrophy type 1. The mechanisms that underlie repeat instability in the germ line and in the somatic tissues of human patients are undefined. Using a selection assay ba...

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Bibliographic Details
Main Authors: Hubert, Leroy, Lin, Yunfu, Dion, Vincent, Wilson, John H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147608/
https://ncbi.nlm.nih.gov/pubmed/21628532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05158-11
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