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Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1

Expansion of trinucleotide repeats (TNRs) is responsible for a number of human neurodegenerative disorders. The molecular mechanisms that underlie TNR instability in humans are not clear. Based on results from model systems, several mechanisms for instability have been proposed, all of which focus o...

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Bibliografiska uppgifter
Huvudupphovsmän: Hubert, Leroy, Lin, Yunfu, Dion, Vincent, Wilson, John H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2011
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221534/
https://ncbi.nlm.nih.gov/pubmed/21926083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr421
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