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Dnmt1 Deficiency Promotes CAG Repeat Expansion in the Mouse Germline
Expanded CAG repeat tracts are the cause of at least a dozen neurodegenerative disorders. In humans, long CAG repeats tend to expand during transmissions from parent to offspring, leading to an earlier age of disease onset and more severe symptoms in subsequent generations. Here, we show that the ma...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2008
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3686304/ https://ncbi.nlm.nih.gov/pubmed/18252747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn019 |
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