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Genome-Wide Demethylation Promotes Triplet Repeat Instability Independently of Homologous Recombination
Trinucleotide repeat instability is intrinsic to a family of human neurodegenerative diseases. The mechanism leading to repeat length variation is unclear. We previously showed that treatment with the demethylating agent 5-aza-2′-deoxycytidine (5-aza-CdR) dramatically increases triplet repeat instab...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2235822/ https://ncbi.nlm.nih.gov/pubmed/18083071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2007.11.002 |
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