Identification of epigenetic DNA modifications with a protein nanopore

Two DNA bases, 5-methyl cytosine (5mC) and 5-hydroxymethylcytosine (hmC), marks of epigenetic modification, are recognized in immobilized DNA strands and distinguished from G, A, T and C by nanopore current recording. Therefore, if further aspects of nanopore sequencing can be addressed, the approac...

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Hlavní autoři: Wallace, Emma V. B., Stoddart, David, Heron, Andrew J., Mikhailova, Ellina, Maglia, Giovanni, Donohoe, Timothy J., Bayley, Hagan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147113/
https://ncbi.nlm.nih.gov/pubmed/20927439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0cc02864a
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