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Nucleobase recognition in ssDNA at the central constriction of the αhemolysin pore

Nanopores are under investigation for single-molecule DNA sequencing. The α-hemolysin (αHL) protein nanopore contains three recognition points capable of nucleobase discrimination in individual immobilized ssDNA molecules. We have modified the recognition point R(1) by extensive mutagenesis of resid...

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Autores principales: Stoddart, David, Heron, Andrew J., Klingelhoefer, Jochen, Mikhailova, Ellina, Maglia, Giovanni, Bayley, Hagan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935931/
https://ncbi.nlm.nih.gov/pubmed/20704324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nl101955a
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