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Enhanced translocation of single DNA molecules through α-hemolysin nanopores by manipulation of internal charge

Both protein and solid-state nanopores are under intense investigation for the analysis of nucleic acids. A crucial advantage of protein nanopores is that site-directed mutagenesis permits precise tuning of their properties. Here, by augmenting the internal positive charge within the α-hemolysin por...

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Autors principals: Maglia, Giovanni, Restrepo, Marcela Rincon, Mikhailova, Ellina, Bayley, Hagan
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2604925/
https://ncbi.nlm.nih.gov/pubmed/19060213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808296105
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