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3-METHYL-3-DEAZAADENINE, A STABLE ISOSTERE OF N3-METHYL-ADENINE, IS EFFICIENTLY BYPASSED BY REPLICATION IN VIVO AND BY TRANSCRIPTION IN VITRO
The goal of the present work was to determine the impact of N3-methyladenine (3-mA), an important lesion generated by many environmental agents and anticancer drugs, on in vivo DNA replication and in vitro RNA transcription. Due to 3-mA chemical instability, the stable isostere 3-methyl-3-deazaadeni...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3146564/ https://ncbi.nlm.nih.gov/pubmed/21676659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2011.05.005 |
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