High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells

We have investigated the mutagenicity induced at the Hprt locus in Chinese hamster ovary (CHO) cells treated with increasing concentrations of Me-lex, a minor groove selective methylating agent that efficiently generates more than 90-95% of 3-MeA DNA adducts. Me-lex treatment was cytotoxic but weakl...

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Detaylı Bibliyografya
Asıl Yazarlar: Russo, Debora, Fronza, Gilberto, Ottaggio, Laura, Monti, Paola, Inga, Alberto, Iyer, Prema, Gold, Barry, Menichini, Paola
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2783936/
https://ncbi.nlm.nih.gov/pubmed/19729030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2009.08.013
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