3-METHYL-3-DEAZAADENINE, A STABLE ISOSTERE OF N3-METHYL-ADENINE, IS EFFICIENTLY BYPASSED BY REPLICATION IN VIVO AND BY TRANSCRIPTION IN VITRO

The goal of the present work was to determine the impact of N3-methyladenine (3-mA), an important lesion generated by many environmental agents and anticancer drugs, on in vivo DNA replication and in vitro RNA transcription. Due to 3-mA chemical instability, the stable isostere 3-methyl-3-deazaadeni...

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Detalhes bibliográficos
Main Authors: Monti, Paola, Broxson, Christopher, Inga, Alberto, Wang, Ruo-wen, Menichini, Paola, Tornaletti, Silvia, Gold, Barry, Fronza, Gilberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146564/
https://ncbi.nlm.nih.gov/pubmed/21676659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2011.05.005
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