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Effect of N3-Methyladenine and an Isosteric Stable Analogue on DNA Polymerization
N3-methyladenine (3-mA) is a cytotoxic lesion formed by the reaction of DNA with many methylating agents, including antineoplastic drugs, environmental agents and endogenously generated compounds. The toxicity of 3-mA has been attributed to its ability to block DNA polymerization. Using Me-lex, a co...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE-Hindawi Access to Research
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2945674/ https://ncbi.nlm.nih.gov/pubmed/20936169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2010/426505 |
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