XRCC1 deficiency influences the cytotoxicity and the genomic instability induced by Me-lex, a specific inducer of N3-methyladenine

Me-lex is a sequence-specific alkylating agent synthesized to preferentially (> 90%) generate N3-methyladenine (3-mA) in the minor groove of double-strand DNA, in A-T rich regions. In this paper we investigated the effect of XRCC1 deficiency in the processing of 3-mA adducts generated by Me-lex,...

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Detalhes bibliográficos
Main Authors: Russo, Debora, Fronza, Gilberto, Ottaggio, Laura, Monti, Paola, Perfumo, Chiara, Inga, Alberto, Iyer, Prema, Gold, Barry, Menichini, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893271/
https://ncbi.nlm.nih.gov/pubmed/20471330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.03.016
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