Dominant-negative features of mutant p53 in germline carriers have limited impact on cancer outcomes

Germline TP53 mutations result in cancer proneness syndromes known as Li-Fraumeni, Li-Fraumeni-like, and nonsyndromic predisposition with or without family history. To explore genotype/phenotype associations, we previously adopted a functional classification of all germline p53 mutant alleles based...

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Detalhes bibliográficos
Main Authors: Monti, Paola, Perfumo, Chiara, Bisio, Alessandra, Ciribilli, Yari, Menichini, Paola, Russo, Debora, Umbach, David M., Resnick, Michael A., Inga, Alberto, Fronza, Gilberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077904/
https://ncbi.nlm.nih.gov/pubmed/21343334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-10-0496
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