p53 Transactivation and the Impact of Mutations, Cofactors and Small Molecules Using a Simplified Yeast-Based Screening System

BACKGROUND: The p53 tumor suppressor, which is altered in most cancers, is a sequence-specific transcription factor that is able to modulate the expression of many target genes and influence a variety of cellular pathways. Inactivation of the p53 pathway in cancer frequently occurs through the expre...

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Autori principali: Andreotti, Virginia, Ciribilli, Yari, Monti, Paola, Bisio, Alessandra, Lion, Mattia, Jordan, Jennifer, Fronza, Gilberto, Menichini, Paola, Resnick, Michael A., Inga, Alberto
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107237/
https://ncbi.nlm.nih.gov/pubmed/21674059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020643
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