Rev1 and Polζ influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent.

The relative toxicity and mutagenicity of Me-lex, which selectively generates 3-methyladenine (3-MeA), is dependent on the nature of the DNA repair background. Base Excision Repair (BER) defective S. cerevisiae strains mag1 and apn1apn2 were both significantly more sensitive to Me-lex toxicity, but...

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Bibliographic Details
Main Authors:	Monti, Paola, Ciribilli, Yari, Russo, Debora, Bisio, Alessandra, Perfumo, Chiara, Andreotti, Virginia, Menichini, Paola, Inga, Alberto, Huang, Xiaofen, Gold, Barry, Fronza, Gilberto
Format:	Artigo
Language:	Inglês
Published:	2008
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2289995/ https://ncbi.nlm.nih.gov/pubmed/18182332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2007.11.015
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Rev1 and Polζ influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent.

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