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XRCC1 deficiency influences the cytotoxicity and the genomic instability induced by Me-lex, a specific inducer of N3-methyladenine
Me-lex is a sequence-specific alkylating agent synthesized to preferentially (> 90%) generate N3-methyladenine (3-mA) in the minor groove of double-strand DNA, in A-T rich regions. In this paper we investigated the effect of XRCC1 deficiency in the processing of 3-mA adducts generated by Me-lex,...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2893271/ https://ncbi.nlm.nih.gov/pubmed/20471330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.03.016 |
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