Autophagy induced by SAHA affects mutant P53 degradation and cancer cell survival

Missense mutations in the TP53 gene produce mutant p53 (mutp53) proteins which may acquire oncogenic properties favoring chemoresistance, cell migration, and metastasis. The exploitation of cellular pathways that promote mutp53 degradation may reduce cell proliferation and invasion as well as increa...

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Podrobná bibliografie
Vydáno v:Biosci Rep
Hlavní autoři: Foggetti, Giorgia, Ottaggio, Laura, Russo, Debora, Mazzitelli, Carlotta, Monti, Paola, Degan, Paolo, Miele, Mariangela, Fronza, Gilberto, Menichini, Paola
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379511/
https://ncbi.nlm.nih.gov/pubmed/30745455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20181345
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