Etoposide-resistance in a neuroblastoma model cell line is associated with 13q14.3 mono-allelic deletion and miRNA-15a/16-1 down-regulation

Drug resistance is the major obstacle in successfully treating high-risk neuroblastoma. The aim of this study was to investigate the basis of etoposide-resistance in neuroblastoma. To this end, a MYCN-amplified neuroblastoma cell line (HTLA-230) was treated with increasing etoposide concentrations a...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Marengo, Barbara, Monti, Paola, Miele, Mariangela, Menichini, Paola, Ottaggio, Laura, Foggetti, Giorgia, Pulliero, Alessandra, Izzotti, Alberto, Speciale, Andrea, Garbarino, Ombretta, Traverso, Nicola, Fronza, Gilberto, Domenicotti, Cinzia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137223/
https://ncbi.nlm.nih.gov/pubmed/30213983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32195-7
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