Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis

Mutations in both RAS and the PTEN/PIK3CA/AKT signaling module are found in the same human tumors. PIK3CA and AKT are downstream effectors of RAS, and the selective advantage conferred by mutation of two genes in the same pathway is unclear. Based on a comparative molecular analysis, we show that ac...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kennedy, Alyssa L., Morton, Jennifer P., Manoharan, Indrani, Nelson, David M., Jamieson, Nigel B., Pawlikowski, Jeff S., McBryan, Tony, Doyle, Brendan, Oien, Karin A., Enders, Greg H., Zhang, Rugang, Sansom, Owen J., Adams, Peter D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145340/
https://ncbi.nlm.nih.gov/pubmed/21474066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.02.020
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