Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis

Mutations in both RAS and the PTEN/PIK3CA/AKT signaling module are found in the same human tumors. PIK3CA and AKT are downstream effectors of RAS, and the selective advantage conferred by mutation of two genes in the same pathway is unclear. Based on a comparative molecular analysis, we show that ac...

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Главные авторы: Kennedy, Alyssa L., Morton, Jennifer P., Manoharan, Indrani, Nelson, David M., Jamieson, Nigel B., Pawlikowski, Jeff S., McBryan, Tony, Doyle, Brendan, Oien, Karin A., Enders, Greg H., Zhang, Rugang, Sansom, Owen J., Adams, Peter D.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145340/
https://ncbi.nlm.nih.gov/pubmed/21474066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.02.020
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