Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis

Mutations in both RAS and the PTEN/PIK3CA/AKT signaling module are found in the same human tumors. PIK3CA and AKT are downstream effectors of RAS, and the selective advantage conferred by mutation of two genes in the same pathway is unclear. Based on a comparative molecular analysis, we show that ac...

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Detalhes bibliográficos
Main Authors: Kennedy, Alyssa L., Morton, Jennifer P., Manoharan, Indrani, Nelson, David M., Jamieson, Nigel B., Pawlikowski, Jeff S., McBryan, Tony, Doyle, Brendan, Oien, Karin A., Enders, Greg H., Zhang, Rugang, Sansom, Owen J., Adams, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145340/
https://ncbi.nlm.nih.gov/pubmed/21474066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.02.020
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