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BRG1 Is Required for Formation of Senescence-Associated Heterochromatin Foci Induced by Oncogenic RAS or BRCA1 Loss

Cellular senescence is an important tumor suppression mechanism. We have previously reported that both oncogene-induced dissociation of BRCA1 from chromatin and BRCA1 knockdown itself drive senescence by promoting formation of senescence-associated heterochromatin foci (SAHF). However, the molecular...

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Detalhes bibliográficos
Main Authors: Tu, Zhigang, Zhuang, Xinying, Yao, Yong-Gang, Zhang, Rugang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624184/
https://ncbi.nlm.nih.gov/pubmed/23438604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01744-12
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