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RAS, cellular senescence and transformation: The BRCA1 DNA repair pathway at the crossroads
The definition of an oncogene is a gene that actively promotes tumorigenesis. For example, activation of RAS oncogene promotes cell transformation and cancer. Paradoxically, in primary mammalian cells, oncogenic RAS typically triggers cellular senescence, a state of irreversible cell growth arrest....
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3442802/ https://ncbi.nlm.nih.gov/pubmed/22751483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.19884 |
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