Oncogenic Ras regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence

Here, we report a cell-intrinsic mechanism by which oncogenic RAS promotes senescence while predisposing cells to senescence bypass by allowing for secondary hits. We show that oncogenic RAS inactivates the BRCA1 DNA repair complex by dissociating BRCA1 from chromatin. This event precedes senescence...

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Bibliographic Details
Main Authors: Tu, Zhigang, Aird, Katherine M., Bitler, Benjamin G., Nicodemus, Jasmine P., Beeharry, Neil, Xia, Bing, Yen, Tim J., Zhang, Rugang
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241855/
https://ncbi.nlm.nih.gov/pubmed/22137763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.10.010
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