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Nucleotide Metabolism, Oncogene-Induced Senescence and Cancer

Senescence is defined as a stable cell growth arrest. Oncogene-induced senescence (OIS) occurs when an activated oncogene is expressed in a normal cell. OIS acts as a bona fide tumor suppressor mechanism by driving stable growth arrest of cancer progenitor cells harboring the initial oncogenic hit....

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Bibliographic Details
Main Authors: Aird, Katherine M., Zhang, Rugang
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115046/
https://ncbi.nlm.nih.gov/pubmed/24486217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2014.01.017
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