Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence

Oncogene-induced senescence is characterized by a stable cell growth arrest, thus providing a tumor suppression mechanism. However, the underlying mechanisms for this phenomenon remain unknown. Here we show that a decrease in deoxyribonucleotide triphosphates (dNTPs) levels underlies oncogene-induce...

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Detalhes bibliográficos
Main Authors: Aird, Katherine M., Zhang, Gao, Li, Hua, Tu, Zhigang, Bitler, Benjamin G., Garipov, Azat, Wu, Hong, Wei, Zhi, Wagner, Stephan N., Herlyn, Meenhard, Zhang, Rugang
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840499/
https://ncbi.nlm.nih.gov/pubmed/23562156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.03.004
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