Synergistic Interactions between HDAC and Sirtuin Inhibitors in Human Leukemia Cells

Aberrant histone deacetylase (HDAC) activity is frequent in human leukemias. However, while classical, NAD(+)-independent HDACs are an established therapeutic target, the relevance of NAD(+)-dependent HDACs (sirtuins) in leukemia treatment remains unclear. Here, we assessed the antileukemic activity...

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Detalhes bibliográficos
Main Authors: Cea, Michele, Soncini, Debora, Fruscione, Floriana, Raffaghello, Lizzia, Garuti, Anna, Emionite, Laura, Moran, Eva, Magnone, Mirko, Zoppoli, Gabriele, Reverberi, Daniele, Caffa, Irene, Salis, Annalisa, Cagnetta, Antonia, Bergamaschi, Micaela, Casciaro, Salvatore, Pierri, Ivana, Damonte, Gianluca, Ansaldi, Filippo, Gobbi, Marco, Pistoia, Vito, Ballestrero, Alberto, Patrone, Franco, Bruzzone, Santina, Nencioni, Alessio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144930/
https://ncbi.nlm.nih.gov/pubmed/21818379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022739
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