Catastrophic NAD(+) Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE

Nicotinamide phosphoribosyltransferase (Nampt) inhibitors such as FK866 are potent inhibitors of NAD(+) synthesis that show promise for the treatment of different forms of cancer. Based on Nampt upregulation in activated T lymphocytes and on preliminary reports of lymphopenia in FK866 treated patien...

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Autors principals: Bruzzone, Santina, Fruscione, Floriana, Morando, Sara, Ferrando, Tiziana, Poggi, Alessandro, Garuti, Anna, D'Urso, Agustina, Selmo, Martina, Benvenuto, Federica, Cea, Michele, Zoppoli, Gabriele, Moran, Eva, Soncini, Debora, Ballestrero, Alberto, Sordat, Bernard, Patrone, Franco, Mostoslavsky, Raul, Uccelli, Antonio, Nencioni, Alessio
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774509/
https://ncbi.nlm.nih.gov/pubmed/19936064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007897
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