The NAD(+)-dependent Histone Deacetylase SIRT6 Promotes Cytokine Production and Migration in Pancreatic Cancer Cells by Regulating Ca(2+) Responses

Cytokine secretion by cancer cells contributes to cancer-induced symptoms and angiogenesis. Studies show that the sirtuin SIRT6 promotes inflammation by enhancing TNF expression. Here, we aimed to determine whether SIRT6 is involved in conferring an inflammatory phenotype to cancer cells and to defi...

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Bibliographische Detailangaben
Hauptverfasser: Bauer, Inga, Grozio, Alessia, Lasigliè, Denise, Basile, Giovanna, Sturla, Laura, Magnone, Mirko, Sociali, Giovanna, Soncini, Debora, Caffa, Irene, Poggi, Alessandro, Zoppoli, Gabriele, Cea, Michele, Feldmann, Georg, Mostoslavsky, Raul, Ballestrero, Alberto, Patrone, Franco, Bruzzone, Santina, Nencioni, Alessio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510797/
https://ncbi.nlm.nih.gov/pubmed/23086953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.405837
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