CD73 Protein as a Source of Extracellular Precursors for Sustained NAD(+) Biosynthesis in FK866-treated Tumor Cells

NAD(+) is mainly synthesized in human cells via the “salvage” pathways starting from nicotinamide, nicotinic acid, or nicotinamide riboside (NR). The inhibition with FK866 of the enzyme nicotinamide phosphoribosyltransferase (NAMPT), catalyzing the first reaction in the “salvage” pathway from nicoti...

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Detalhes bibliográficos
Main Authors: Grozio, Alessia, Sociali, Giovanna, Sturla, Laura, Caffa, Irene, Soncini, Debora, Salis, Annalisa, Raffaelli, Nadia, De Flora, Antonio, Nencioni, Alessio, Bruzzone, Santina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764798/
https://ncbi.nlm.nih.gov/pubmed/23880765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.470435
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