A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis

APO866, an inhibitor of NAD biosynthesis, exhibits potent antitumor properties in various malignancies. Recently, it has been shown that APO866 induces apoptosis and autophagy in human hematological cancer cells, but the role of autophagy in APO866-induced cell death remains unclear. Here, we report...

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Detalhes bibliográficos
Main Authors: Ginet, Vanessa, Puyal, Julien, Rummel, Coralie, Aubry, Dominique, Breton, Caroline, Cloux, Anne-Julie, Majjigapu, Somi R, Sordat, Bernard, Vogel, Pierre, Bruzzone, Santina, Nencioni, Alessio, Duchosal, Michel A, Nahimana, Aimable
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Basic Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091148/
https://ncbi.nlm.nih.gov/pubmed/24487122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.27722
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