Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent

APO866 is a small molecule drug that specifically inhibits nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme involved in nicotinamide adenine dinucleotide (NAD) biosynthesis from the natural precursor nicotinamide. Although, the antitumor activity of APO866 on various types of cancer mode...

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Udgivet i:Oncotarget
Main Authors: Cloux, Anne-Julie, Aubry, Dominique, Heulot, Mathieu, Widmann, Christian, ElMokh, Oussama, Piacente, Francesco, Cea, Michele, Nencioni, Alessio, Bellotti, Axel, Bouzourène, Karima, Pellegrin, Maxime, Mazzolai, Lucia, Duchosal, Michel A., Nahimana, Aimable
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877101/
https://ncbi.nlm.nih.gov/pubmed/31803365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27336
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