A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis

APO866, an inhibitor of NAD biosynthesis, exhibits potent antitumor properties in various malignancies. Recently, it has been shown that APO866 induces apoptosis and autophagy in human hematological cancer cells, but the role of autophagy in APO866-induced cell death remains unclear. Here, we report...

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Autors principals: Ginet, Vanessa, Puyal, Julien, Rummel, Coralie, Aubry, Dominique, Breton, Caroline, Cloux, Anne-Julie, Majjigapu, Somi R, Sordat, Bernard, Vogel, Pierre, Bruzzone, Santina, Nencioni, Alessio, Duchosal, Michel A, Nahimana, Aimable
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2014
Matèries:
Basic Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091148/
https://ncbi.nlm.nih.gov/pubmed/24487122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.27722
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