A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis

APO866, an inhibitor of NAD biosynthesis, exhibits potent antitumor properties in various malignancies. Recently, it has been shown that APO866 induces apoptosis and autophagy in human hematological cancer cells, but the role of autophagy in APO866-induced cell death remains unclear. Here, we report...

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Dettagli Bibliografici
Autori principali: Ginet, Vanessa, Puyal, Julien, Rummel, Coralie, Aubry, Dominique, Breton, Caroline, Cloux, Anne-Julie, Majjigapu, Somi R, Sordat, Bernard, Vogel, Pierre, Bruzzone, Santina, Nencioni, Alessio, Duchosal, Michel A, Nahimana, Aimable
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2014
Soggetti:
Basic Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091148/
https://ncbi.nlm.nih.gov/pubmed/24487122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.27722
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