SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells

Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the NAD(+) salvage pathway from nicotinamide. By controlling the biosynthesis of NAD(+), NAMPT regulates the activity of NAD(+)-converting enzymes, such as CD38, poly-ADP-ribose polymerases, and sirtuins (SIRTs). SIRT6 is...

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Dettagli Bibliografici
Pubblicato in:FASEB J
Autori principali: Sociali, Giovanna, Grozio, Alessia, Caffa, Irene, Schuster, Susanne, Becherini, Pamela, Damonte, Patrizia, Sturla, Laura, Fresia, Chiara, Passalacqua, Mario, Mazzola, Francesca, Raffaelli, Nadia, Garten, Antje, Kiess, Wieland, Cea, Michele, Nencioni, Alessio, Bruzzone, Santina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988859/
https://ncbi.nlm.nih.gov/pubmed/30514106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800321R
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