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Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells

BACKGROUND: Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide adenine dinucleotide (NAD) levels are crucial for liver function. The saturated fatty acid palmitate and the unsaturated fatty acid oleate are the main free fatty acids in adipose tissue and human diet. We asked how these fa...

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Detalhes bibliográficos
Publicado no:Lipids Health Dis
Main Authors: Penke, Melanie, Schuster, Susanne, Gorski, Theresa, Gebhardt, Rolf, Kiess, Wieland, Garten, Antje
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627432/
https://ncbi.nlm.nih.gov/pubmed/28974242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12944-017-0583-6
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