Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.

Nicotinamide phosphoribosyltransferase (Nampt) inhibitors such as FK866 are potent inhibitors of NAD(+) synthesis that show promise for the treatment of different forms of cancer. Based on Nampt upregulation in activated T lymphocytes and on preliminary reports of lymphopenia in FK866 treated patien...

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Main Authors: Santina Bruzzone, Floriana Fruscione, Sara Morando, Tiziana Ferrando, Alessandro Poggi, Anna Garuti, Agustina D'Urso, Martina Selmo, Federica Benvenuto, Michele Cea, Gabriele Zoppoli, Eva Moran, Debora Soncini, Alberto Ballestrero, Bernard Sordat, Franco Patrone, Raul Mostoslavsky, Antonio Uccelli, Alessio Nencioni
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2009-11-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC2774509?pdf=render
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