Evidence for a stromal-epithelial “lactate shuttle” in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts

Recently, we proposed a new mechanism for understanding the Warburg effect in cancer metabolism. In this new paradigm, cancer-associated fibroblasts undergo aerobic glycolysis, and extrude lactate to “feed” adjacent cancer cells, which then drives mitochondrial biogenesis and oxidative mitochondrial...

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Bibliografiske detaljer
Main Authors: Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E, Lin, Zhao, Ertel, Adam, Flomenberg, Neal, Witkiewicz, Agnieszka K, Birbe, Ruth C, Howell, Anthony, Pavlides, Stephanos, Gandara, Ricardo, Pestell, Richard G, Sotgia, Federica, Philp, Nancy J, Lisanti, Michael P
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2011
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142461/
https://ncbi.nlm.nih.gov/pubmed/21558814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.11.15659
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