Mitochondrial metabolism in cancer metastasis: Visualizing tumor cell mitochondria and the “reverse Warburg effect” in positive lymph node tissue

We have recently proposed a new two-compartment model for understanding the Warburg effect in tumor metabolism. In this model, glycolytic stromal cells produce mitochondrial fuels (L-lactate and ketone bodies) that are then transferred to oxidative epithelial cancer cells, driving OXPHOS and mitocho...

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Autores principales: Sotgia, Federica, Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E, Flomenberg, Neal, Birbe, Ruth C, Witkiewicz, Agnieszka K, Howell, Anthony, Philp, Nancy J, Pestell, Richard G, Lisanti, Michael P
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350881/
https://ncbi.nlm.nih.gov/pubmed/22395432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.19841
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