Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

Zinc-finger nucleases (ZFNs) are powerful tools for producing gene knockouts (KOs) with high efficiency. Whereas ZFN-mediated gene disruption has been demonstrated in laboratory animals such as mice, rats, and fruit flies, ZFNs have not been used to disrupt an endogenous gene in any large domestic s...

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Main Authors: Hauschild, Janet, Petersen, Bjoern, Santiago, Yolanda, Queisser, Anna-Lisa, Carnwath, Joseph W., Lucas-Hahn, Andrea, Zhang, Lei, Meng, Xiangdong, Gregory, Philip D., Schwinzer, Reinhard, Cost, Gregory J., Niemann, Heiner
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2011
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141985/
https://ncbi.nlm.nih.gov/pubmed/21730124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106422108
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