Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

Zinc-finger nucleases (ZFNs) are powerful tools for producing gene knockouts (KOs) with high efficiency. Whereas ZFN-mediated gene disruption has been demonstrated in laboratory animals such as mice, rats, and fruit flies, ZFNs have not been used to disrupt an endogenous gene in any large domestic s...

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Detalles Bibliográficos
Autores principales: Hauschild, Janet, Petersen, Bjoern, Santiago, Yolanda, Queisser, Anna-Lisa, Carnwath, Joseph W., Lucas-Hahn, Andrea, Zhang, Lei, Meng, Xiangdong, Gregory, Philip D., Schwinzer, Reinhard, Cost, Gregory J., Niemann, Heiner
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141985/
https://ncbi.nlm.nih.gov/pubmed/21730124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106422108
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