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Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases
Zinc-finger nucleases (ZFNs) are powerful tools for producing gene knockouts (KOs) with high efficiency. Whereas ZFN-mediated gene disruption has been demonstrated in laboratory animals such as mice, rats, and fruit flies, ZFNs have not been used to disrupt an endogenous gene in any large domestic s...
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| Auteurs principaux: | , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3141985/ https://ncbi.nlm.nih.gov/pubmed/21730124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106422108 |
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