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Inactivation of Multidrug Resistance Proteins Disrupts Both Cellular Extrusion and Intracellular Degradation of cAMP

In addition to xenobiotics and several other endogenous metabolites, multidrug-resistance proteins (MRPs) extrude the second-messenger cAMP from various cells. Pharmacological and/or genetic inactivation of MRPs has been shown to augment intracellular cAMP signaling, an effect assumed to be a direct...

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Bibliographische Detailangaben
Hauptverfasser: Xie, Moses, Rich, Thomas C., Scheitrum, Colleen, Conti, Marco, Richter, Wito
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141887/
https://ncbi.nlm.nih.gov/pubmed/21551375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.071134
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