Reversing established sepsis with antagonists of endogenous high-mobility group box 1

Despite significant advances in intensive care therapy and antibiotics, severe sepsis accounts for 9% of all deaths in the United States annually. The pathological sequelae of sepsis are characterized by a systemic inflammatory response, but experimental therapeutics that target specific early infla...

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Main Authors: Yang, Huan, Ochani, Mahendar, Li, Jianhua, Qiang, Xiaoling, Tanovic, Mahira, Harris, Helena E., Susarla, Srinivas M., Ulloa, Luis, Wang, Hong, DiRaimo, Robert, Czura, Christopher J., Wang, Haichao, Roth, Jesse, Warren, H. Shaw, Fink, Mitchell P., Fenton, Matthew J., Andersson, Ulf, Tracey, Kevin J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC314179/
https://ncbi.nlm.nih.gov/pubmed/14695889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2434651100
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