Activation of factor XI by products of prothrombin activation

The prothrombinase complex converts prothrombin to α-thrombin through the intermediate meizothrombin (Mz-IIa). Both α-thrombin and Mz-IIa catalyze factor (F) XI activation to FXIa, which sustains α-thrombin production through activation of FIX. The interaction with FXI is thought to involve thrombin...

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Bibliographic Details
Main Authors: Matafonov, Anton, Sarilla, Suryakala, Sun, Mao-fu, Sheehan, John P., Serebrov, Vladimir, Verhamme, Ingrid M., Gailani, David
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Thrombosis and Hemostasis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138693/
https://ncbi.nlm.nih.gov/pubmed/21527525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-312983
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