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The Formamidopyrimidine Derivative of 7-(2-Oxoethyl)-2′-deoxyguanosine
Vinyl chloride induces hepatic angiosarcomas, which are otherwise rare malignancies. The biochemical basis involves the formation of the epoxide, which reacts with DNA to give ~98% of the 7-(2-oxoethyl) adduct (4) of dGuo plus small amounts of the etheno derivatives of dGuo, dCyd, and dAdo. The carc...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3138534/ https://ncbi.nlm.nih.gov/pubmed/18690723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800142m |
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